p53 Knockout Rat
Model Detail >
Heterozygous or Homozygous
- Vaccine development
- Autoimmune disease
- Infectious disease
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Homozygous null Tp53 rats display onset of tumors at ~4 months of age. A high degree of malignancy is observed across a broad spectrum of tumors. Heterozygous rats have a delayed onset of spontaneous tumors, making them valuable for carcinogenicity screening, as well as studying efficacy of chemopreventive and therapeutic treatment.
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- Monoallelic 11 base pair deletion in Tp53
- Broad tumor spectrum
- High degree of tumor malignancy
- Background Strain: Sprague-Dawley
Table 1. Tp53 (+/-) Tumor Spectrum
Table 2. Tp53 (-/-) Tumor Spectrum
Figure 1. Survival rates of both heterozygous and homozygous p53 null rats (n = 30)
p53 is a tumor suppressor protein encoded by the Tp53 gene. Its role in cell cycle regulation and stabilization for preventing genome mutation is observable among a wide variety of multicellular organisms, including humans, rodents, frogs and fish. Heterozygous rats deficient in p53 protein are prone to spontaneous tumors, making them valuable for in vivo screening of carcinogenicity, as well as studying chemopreventive and therapeutic treatment.
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