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Lrrk2 Knockout Rat
Model Detail >
Blue Fade Line
Nomenclature: LEH- Lrrk2 tm1sage
Genotype: Homozygous
Product number: TGRL4620
Research Applications
  • Parkinson's disease
  • Neuronal apoptosis
Description

Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson’s disease. This model is useful in understanding Lrrk2 biology.

Download our review of Animal Models of Parkinson's Disease.

Characteristics
  • Homozygous knockout rats exhibit complete loss of target protein as demonstrated by Western blot
  • Lrrk2 knockout rats display dark kidneys, similar to observations made in Lrrk2 knockout mice
  • Lrrk2 knockout rats are significantly larger than wild type controls
  • Background Strain: Long Evans Hooded
  • Figure 1. Kidney pathology in Lrrk2 knockout rats
    Kidney from a Lrrk2 knockout rat at 37 weeks of age. The kidney is dark in color, a phenotype similar to observations in Lrrk2 knockout mice (Herzig MC, et al. Hum Mol Genet (2011) 20 (21): 4209–4223). Image courtesy of PsychoGenics.

    Figure 2. Rotarod performance of Lrrk2 knockout rats at 12 months of age
    Lrrk2 knockout animals show no deficits in motor activity as assessed by rotarod at 12 months of age.

    Additional Information

    Lrrk2 mutations account for 5-6% of familial Parkinson’s dieases and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson’s disease.

    Publications

  • Deficient Rats Exhibit Renal Tubule Injury and Perturbations in Metabolic and Immunological Homeostasis
  • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
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